Effective Immunization with Live Attenuated Influenza A Virus Can Be Achieved in Early Infancy

Seasonal influenza immunization in early infancy?

Seasonal influenza is an important public health and medical challenge. Vaccination against influenza is recognized worldwide as the main strategy for prevention and control. The findings of meta-analyses, however, suggest that efficacy and effectiveness of influenza vaccines, both in people aged 65 years or older [1] and in children, are lower than believed [2]. These findings were recently co...

Mass immunization of children in Iran with live attenuated Sugiyama measles virus adapted to calf kidney cell cultures

Molecular Basis of Live-Attenuated Influenza Virus

Human influenza is a seasonal disease associated with significant morbidity and mortality. The most effective means for controlling infection and thereby reducing morbidity and mortality is vaccination with a three inactivated influenza virus strains mixture, or by intranasal administration of a group of three different live attenuated influenza vaccine strains. Comparing to the inactivated vac...

Studies with live attenuated influenza virus in chronic bronchitis.

The use of live, recombinant virus for immunisation against influenza produced a number of respiratory illnesses, some severe, in patients with chronic obstructive airways disease. These patients are probably more susceptible to the influenza virus than are normal subjects. Special care will be needed in testing these viruses on patients with respiratory disease.

Sublingual Immunization with a Live Attenuated Influenza A Virus Lacking the Nonstructural Protein 1 Induces Broad Protective Immunity in Mice

The nonstructural protein 1 (NS1) of influenza A virus (IAV) enables the virus to disarm the host cell type 1 IFN defense system. Mutation or deletion of the NS1 gene leads to attenuation of the virus and enhances host antiviral response making such live-attenuated influenza viruses attractive vaccine candidates. Sublingual (SL) immunization with live influenza virus has been found to be safe a...